The following companies were founded to commercialize innovations that grew out of research at UCI.
- AbaStarMDX ™, Inc.

- Actavalon, Inc.
- Aerin, Inc.
- Airmid, Inc.
- ALEKS, Inc.
- Anteana Therapeutics
- Antigen Discovery, Inc.
- Anvyl ,LLC
- Applied Oncology Innovations
- BiMaple, Inc.
- BioSpecimen Technologies, LLC
- Bone-Rad Therapeutics, Inc.
- Cerebra-On, Inc.
- Cortex Pharmaceuticals
- Define QA, Inc.
- DermaLucent
- Endeavors Technologies
- Flint Rehabilitation Devices, LLC
- GK Materials, Inc.
- Glaukos Corporation
- Glixis Therapeutics, LLC
- HiperWall
- Hybrid Plastics, Inc.
- Introspective Medical
- jCyte, Inc.
- Magneto-Inertial Fusion Technologies, Inc. (MIFTI)
- Meyer Pharmaceuticals, Inc.
- Modulating Imaging
- Molecular Vista LLC
- Novoheart, Inc.
- Novonco Therapeutics
- Nurotron Biotechnology, Inc.
- OCT Medical Imaging, Inc
- One-Cycle Control, Inc.
- Orphomed, LLP
- PhageTech, LLC
- Praxis BioSciences, LLC
- Reaction Explorer, LLC
- RF Nano Corp.
- Sclera, LLC
- Shoelace Wireless, Inc.
- Sironis, Inc.
- SoundCure Inc.
- Tamar Technology, Inc.
- Tear Diagno LLC
- Thesan Pharmaceuticals, Inc.
- TinyKicks
- Velox Biosystems,LLC
- Wavefunction, Inc.
- Xona Microfluidics, Inc.
- ZeroWatt Technologies, Inc.